Eickhoff J H, Tfelt-Hansen P
Clin Physiol. 1982 Feb;2(1):29-38. doi: 10.1111/j.1475-097x.1982.tb00004.x.
Local blood flow regulation of the foot was studied in 15 normal subjects and in nine migraine patients. Changes in arterial and venous pressures were induced by lowering and elevation of the limb. Changes in blood flow were estimated from the changes in the wash-out rate of a subcutaneous 133-Xenon depot. The local vasoconstrictor response to increased venous pressure elicited during lowering was identical in the normal subjects and in the migraine patients. During elevation, however, an abnormality in the autoregulation of blood flow could be demonstrated, as a decrease in blood flow during elevation to +40 cm was more pronounced in the patients than in the normal subjects (P = 0.04). About 3 h after 0.5 mg ergotamine tartrate/70 kg body weight i.v. the local regulation of blood flow had markedly changed in normal subjects as well as in migraine patients. During elevation to +20 and to +40 cm, blood flow increased significantly (P = 0.01 and P = 0.02). In two subjects the isotope depot was infiltrated with lidocaine and the ergotamine-induced increase in blood flow during elevation was blocked. The results may indicate that the veno-receptor of the veno-arteriolar reflex underlying the local vasoconstrictor response is a tension receptor, which due to the veno-constrictor effect of ergotamine is triggered even at heart level.
对15名正常受试者和9名偏头痛患者的足部局部血流调节进行了研究。通过抬高和降低肢体来诱导动脉压和静脉压的变化。根据皮下133-氙储存库清除率的变化来估算血流变化。正常受试者和偏头痛患者在降低肢体时对静脉压升高引起的局部血管收缩反应是相同的。然而，在抬高肢体时，可以证明血流自动调节存在异常，因为在抬高到+40厘米时患者的血流减少比正常受试者更明显（P = 0.04）。静脉注射0.5毫克酒石酸麦角胺/70千克体重约3小时后，正常受试者和偏头痛患者的局部血流调节都发生了显著变化。在抬高到+20厘米和+40厘米时，血流显著增加（P = 0.01和P = 0.02）。在两名受试者中，用利多卡因浸润同位素储存库，阻断了抬高肢体期间麦角胺诱导的血流增加。结果可能表明，局部血管收缩反应所基于的静脉-小动脉反射的静脉受体是一种张力受体，由于麦角胺的静脉收缩作用，即使在心脏水平也会被触发。
