Cohan S L
Clin Lab Med. 1981 Sep;1(3):479-500.
The effort to employ therapeutic drug monitoring in the management of patients with convulsive disorders has been extremely successful. Fortunately, the drugs used by the majority of these patients are readily measured in plasma, and in most cases the plasma concentration is a valid measure of the appropriateness of the dosage of drug administered. Monitoring also helps to ensure patient compliance to drug schedules and allows appropriate adjustment of dosage in patients who are taking concomitant drugs that influence anticonvulsant drug levels. Accurate and reliable quantitative methodology is available to all laboratories, with the method of analysis selected reflecting the technical capabilities of the laboratory personnel.
在惊厥性疾病患者管理中采用治疗药物监测的努力取得了极大成功。幸运的是，这些患者中大多数所使用的药物很容易在血浆中进行测定，而且在大多数情况下，血浆浓度是所给药剂量是否合适的有效指标。监测还有助于确保患者遵守用药计划，并能对正在服用影响抗惊厥药物水平的伴随药物的患者进行适当的剂量调整。所有实验室都可获得准确可靠的定量方法，所选择的分析方法反映了实验室人员的技术能力。
