Rockwell S
Int J Radiat Oncol Biol Phys. 1982 Jun;8(6):1035-9. doi: 10.1016/0360-3016(82)90173-0.
Aerobic and hypoxic EMT6 mouse mammary tumor cels in exponential growth in vitro were used to study cell survival after treatment with radiation (250kV X rays) and mitomycin C in various combinations. The cytotoxicities of the two agents were found to be additive as judged by comparing dose-response curves for each agent alone with survival curves after combination therapy and by isobologram analysis. The cytotoxicities resulting from combination treatments were found to be independent of the sequence of the treatments or the interval between treatments.
利用处于体外指数生长期的需氧和缺氧EMT6小鼠乳腺肿瘤细胞，研究其在接受不同组合的辐射（250kV X射线）和丝裂霉素C治疗后的细胞存活率。通过将每种药物单独的剂量反应曲线与联合治疗后的存活曲线进行比较，并通过等效线图分析判断，发现这两种药物的细胞毒性具有相加性。发现联合治疗产生的细胞毒性与治疗顺序或治疗间隔无关。
