前脂肪细胞生长停滞与分化的偶联。II. 细胞增殖生理控制的细胞周期模型。
Coupling of proadipocyte growth arrest and differentiation. II. A cell cycle model for the physiological control of cell proliferation.
作者信息
Scott R E, Hoerl B J, Wille J J, Florine D L, Krawisz B R, Yun K
出版信息
J Cell Biol. 1982 Aug;94(2):400-5. doi: 10.1083/jcb.94.2.400.
Abstract
Experimental evidence is presented that supports a cell cycle model showing that there are five distinct biological processes involved in proadipocyte differentiation. These include: (a) growth arrest at a distinct state in the G1 phase of the cell cycle; (b) nonterminal differentiation; (c) terminal differentiation; (d) loss of the differentiated phenotype; and (e) reinitiation of cell proliferation. Each of these events is shown to be regulated by specific human plasma components or other physiological factors. At two states designated GD and GD', coupling of growth arrest and differentiation is shown to occur. We propose that these mechanisms for the coupling of growth arrest and differentiation are physiologically significant and mimic the regulatory processes that control stem cell proliferation in vivo.
摘要
实验证据表明，支持一种细胞周期模型，该模型显示前脂肪细胞分化涉及五个不同的生物学过程。这些过程包括：(a) 在细胞周期的G1期特定状态下生长停滞；(b) 非终末分化；(c) 终末分化；(d) 分化表型的丧失；以及(e) 细胞增殖的重新启动。这些事件中的每一个都显示受特定人类血浆成分或其他生理因素调节。在指定为GD和GD'的两个状态下，生长停滞与分化的偶联被证明会发生。我们提出，这些生长停滞与分化偶联的机制在生理上具有重要意义，并模拟了体内控制干细胞增殖的调节过程。
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