Thorne C H, Higgins G R, Ulich T R, Gitnick G L, Lewin K J
Arch Pathol Lab Med. 1982 Sep;106(9):433-6.
The histopathologic aspects of 62 cases of chronic active hepatitis (CAH) were examined to compare hepatitis B surface antigen (HBsAg)-positive with HBsAg-negative (non-A, non-B) cases. Epidemiologically, the two groups were distinct. Homosexuals and young, male users of intravenous drugs accounted for most of the cases of hepatitis B CAH, whereas older men and women with a history of blood transfusions represented a large percentage of the HBsAg-negative cases. However, there were no pathologic differences between the two diseases, in severity of inflammatory activity, degree of architectural damage, appearance of the bile ducts, or prevalence of cirrhosis. In a population of hospitalized patients, these two diseases cannot be distinguished microscopically unless hepatocytes that contain HBsAg are demonstrated. Although our current understanding of non-A, non-B CAH is limited, the disease not necessarily remit spontaneously, and progression to cirrhosis can be expected in some cases.
对62例慢性活动性肝炎（CAH）的组织病理学特征进行了检查，以比较乙肝表面抗原（HBsAg）阳性和HBsAg阴性（非甲非乙型）病例。从流行病学角度看，这两组有所不同。同性恋者以及年轻的男性静脉注射毒品使用者占乙肝CAH病例的大多数，而有输血史的老年男性和女性在HBsAg阴性病例中占很大比例。然而，这两种疾病在炎症活动的严重程度、结构破坏程度、胆管外观或肝硬化患病率方面并无病理差异。在住院患者群体中，除非证明存在含HBsAg的肝细胞，否则这两种疾病在显微镜下无法区分。尽管我们目前对非甲非乙型CAH的了解有限，但这种疾病不一定会自发缓解，在某些情况下可能会发展为肝硬化。
