Wheldrake J F, Marshall J, Ramli J, Murray A W
Carcinogenesis. 1982;3(7):805-7. doi: 10.1093/carcin/3.7.805.
The sensitivity of various mouse strains to skin carcinogenesis has been investigated in two ways; (i) by comparing carcinogenesis induced by treatments involving both the application of tumour promoters and the application of single or multiple doses of a carcinogen, and (ii) by comparing the binding characteristics of the tumour promoter [3H]phorbol-12,13-dibutyrate to particulate skin preparations. The mouse strains tested were Swiss albino, Balb/c, C3H, LACA and AKR/J. Although some differences were apparent, Swiss albino, LACA and C3H mice were generally sensitive to skin carcinogenesis by both benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene, either with or without promotion with croton oil. AKR/J mice were sensitive to both carcinogens with promotion but relatively insensitive in the absence of promotion. Balb/c mice had low sensitivity except when exposed to repeated low doses of benzo[a]pyrene. The [3H]phorbol-12,13-dibutyrate binding characteristics of particulate skin preparations from all strains were indistinguishable.
（i）通过比较涉及应用肿瘤促进剂以及单次或多次剂量致癌物的处理所诱导的致癌作用，以及（ii）通过比较肿瘤促进剂[3H]佛波醇-12,13-二丁酸酯与皮肤颗粒制剂的结合特性。所测试的小鼠品系为瑞士白化小鼠、Balb/c、C3H、LACA和AKR/J。尽管存在一些明显差异，但瑞士白化小鼠、LACA和C3H小鼠通常对苯并[a]芘和7,12-二甲基苯并[a]蒽诱导的皮肤致癌作用敏感，无论是否用巴豆油促进。AKR/J小鼠在有促进作用时对两种致癌物均敏感，但在无促进作用时相对不敏感。Balb/c小鼠敏感性较低，除非暴露于反复低剂量的苯并[a]芘。所有品系皮肤颗粒制剂的[3H]佛波醇-12,13-二丁酸酯结合特性无明显差异。
