脱氧胆酸对7,12-二甲基苯并(a)蒽诱导的两阶段小鼠皮肤致癌作用的影响。
Effect of deoxycholic acid on 7,12-dimethylbenz(a)anthracene-induced, two-stage mouse skin carcinogenesis.
作者信息
Glauert H P, Bennink M R
出版信息
Res Commun Chem Pathol Pharmacol. 1978 Dec;22(3):609-12.
PMID:104372
Abstract
The effect of deoxycholic acid on 7,12-dimethylbenz(a)anthracenecroton oil carcinogenesis in mouse skin was tested. Painting deoxycholic acid in addition to croton oil during promotion resulted in the earlier appearance of tumors, a greater tumor incidence, and a larger number of tumors per animal. DMBA initiation followed by either deoxycholic acid or solvents during the promotion period produced no tumors. Animals receiving deoxycholic acid or solvents alone developed no tumors.
摘要
测试了脱氧胆酸对小鼠皮肤中7,12-二甲基苯并(a)蒽巴豆油致癌作用的影响。在促癌阶段除巴豆油外涂抹脱氧胆酸，导致肿瘤更早出现、更高的肿瘤发生率以及每只动物产生更多数量的肿瘤。在促癌期，先用二甲基苯并蒽引发，随后涂抹脱氧胆酸或溶剂，未产生肿瘤。单独接受脱氧胆酸或溶剂的动物未出现肿瘤。
Zotero 插件