Archer D F
Fertil Steril. 1987 Apr;47(4):559-64. doi: 10.1016/s0015-0282(16)59102-x.
Infertile women with normal serum prolactin (PRL) levels have been known to establish a pregnancy after the use of bromocriptine, a dopamine agonist. These data imply that there may be a group of women with a slight but significant increase in PRL secretion that may have resulted in their infertility. This study evaluates the thyrotropin-releasing hormone (TRH)-induced PRL and thyroid-stimulating hormone (TSH) response in normal women (NL, n = 6), women with anovulation and/or inphase endometrial biopsies (AN/IN, n = 12), and women with histologic evidence of luteal phase deficiency (LPD, n = 12). Most of these women were found to have elevated serum PRL values on random testing. There was a statistically significant increase in PRL response at all time intervals after TRH between the NL and AN/IN groups compared with the group with LPD on the basis of repeated measures analysis (P = 0.0013). There was no statistical difference in the TSH response between these three groups. Although the PRL response was statistically different, individual PRL response patterns were not diagnostic. It appears from these data that there is an increased PRL secretion in infertile women who have histological evidence of a LPD.
已知血清催乳素（PRL）水平正常的不孕女性在使用多巴胺激动剂溴隐亭后能够怀孕。这些数据表明，可能存在一组女性，其PRL分泌略有但显著增加，这可能导致了她们的不孕。本研究评估了正常女性（NL，n = 6）、无排卵和/或子宫内膜活检呈分泌期改变的女性（AN/IN，n = 12）以及有黄体期缺陷组织学证据的女性（LPD，n = 12）对促甲状腺激素释放激素（TRH）诱导的PRL和促甲状腺激素（TSH）反应。在随机检测中，发现这些女性中的大多数血清PRL值升高。根据重复测量分析，NL组和AN/IN组在TRH刺激后的所有时间间隔内，PRL反应与LPD组相比有统计学显著增加（P = 0.0013）。这三组之间的TSH反应没有统计学差异。虽然PRL反应有统计学差异，但个体PRL反应模式并无诊断价值。从这些数据来看，有黄体期缺陷组织学证据的不孕女性存在PRL分泌增加的情况。
