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葡萄球菌对大环内酯类、林可酰胺类及B型链阳菌素类抗生素耐药基因在大肠杆菌中的表达

Expression in Escherichia coli of a staphylococcal gene for resistance to macrolide, lincosamide, and streptogramin type B antibiotics.

作者信息

Hardy K, Haefeli C

出版信息

J Bacteriol. 1982 Oct;152(1):524-6. doi: 10.1128/jb.152.1.524-526.1982.

DOI:10.1128/jb.152.1.524-526.1982
PMID:6811564
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC221457/
Abstract

Plasmid pBD9, which comprises two plasmids from Staphylococcus aureus, pE194 and pUB110, was joined to plasmid pBR322 by in vitro recombination to form plasmid pKH80. The ermC gene of plasmid pE194 confers inducible resistance to macrolide, lincosamide, and streptogramin type B antibiotics. When pKH80 was transferred to Escherichia coli K-12, the bacteria became resistant to several of these antibodies.

摘要

质粒pBD9由来自金黄色葡萄球菌的两个质粒pE194和pUB110组成，通过体外重组与质粒pBR322连接，形成质粒pKH80。质粒pE194的ermC基因赋予对大环内酯类、林可酰胺类和B型链阳菌素类抗生素的诱导抗性。当pKH80转移到大肠杆菌K-12中时，该细菌对其中几种抗生素产生抗性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f6e/221457/64658cc78e94/jbacter00251-0537-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f6e/221457/b89b2d0fbe7b/jbacter00251-0537-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f6e/221457/64658cc78e94/jbacter00251-0537-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f6e/221457/b89b2d0fbe7b/jbacter00251-0537-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f6e/221457/64658cc78e94/jbacter00251-0537-b.jpg

相似文献

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Expression in Escherichia coli of a staphylococcal gene for resistance to macrolide, lincosamide, and streptogramin type B antibiotics.葡萄球菌对大环内酯类、林可酰胺类及B型链阳菌素类抗生素耐药基因在大肠杆菌中的表达
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本文引用的文献

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Susceptibility of Proteus mirabilis and its stable L-forms to erythromycin and other macrolides.奇异变形杆菌及其稳定L型对红霉素和其他大环内酯类药物的敏感性。
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Expression of streptococcal plasmid-determined resistance to erythromycin and lincomycin in Escherichia coli.大肠杆菌中链球菌质粒介导的对红霉素和林可霉素耐药性的表达
Mol Gen Genet. 1981;184(2):283-5. doi: 10.1007/BF00272918.
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Posttranscriptional modification of mRNA conformation: mechanism that regulates erythromycin-induced resistance.
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Expression of a cloned Staphylococcus aureus alpha-hemolysin determinant in Bacillus subtilis and Staphylococcus aureus.克隆的金黄色葡萄球菌α-溶血素决定簇在枯草芽孢杆菌和金黄色葡萄球菌中的表达。
Infect Immun. 1983 Sep;41(3):1112-7. doi: 10.1128/iai.41.3.1112-1117.1983.
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A complex attenuator regulates inducible resistance to macrolides, lincosamides, and streptogramin type B antibiotics in Streptococcus sanguis.一种复杂的衰减子调节血链球菌对大环内酯类、林可酰胺类和B型链阳菌素类抗生素的诱导抗性。
J Bacteriol. 1983 Jun;154(3):1252-62. doi: 10.1128/jb.154.3.1252-1262.1983.
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Antibiotic resistance mutations in 16S and 23S ribosomal RNA genes of Escherichia coli.大肠杆菌16S和23S核糖体RNA基因中的抗生素抗性突变
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mRNA构象的转录后修饰：调节红霉素诱导抗性的机制
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Nature. 1981 Oct 8;293(5832):481-3. doi: 10.1038/293481a0.
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8
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Nucleic Acids Res. 1980 Dec 20;8(24):6081-97. doi: 10.1093/nar/8.24.6081.
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