Bonner J J, Tyan M L
J Immunogenet. 1982 Aug;9(4):243-8. doi: 10.1111/j.1744-313x.1982.tb00979.x.
Data presented here defines the map of H-2 associated genes which affect the glucocorticoid-induced cleft palate frequency to the regions H-2K to I-B and G to H-2D. This was done by observing in four congenic strains the frequency of cleft palate induced by 160 mg/kg of dexamethasone administered to pregnant females on day 12 of gestation. The strains used were B10.A/Sg.Sn, C57BL/10Sn, B10.A (5R)/SgSn and B10.A(18R)/Sg. Additionally the cleft palate frequency was observed in a large number of litters from saline-treated pregnant females. The cleft palate frequency in this control was very low and the rank of strains was the same as for the glucocorticoid-induced cleft-palate frequency. This observation suggests that the induced cleft palate frequency reflects the spontaneous occurrence of isolated cleft palate in these strains.
此处呈现的数据确定了与H-2相关的基因图谱，这些基因会影响糖皮质激素诱导的腭裂频率，其涉及的区域从H-2K到I-B以及从G到H-2D。这是通过观察四个同源近交系来完成的，在妊娠第12天给怀孕的雌性小鼠注射160mg/kg地塞米松，然后观察腭裂的发生频率。所使用的品系为B10.A/Sg.Sn、C57BL/10Sn、B10.A(5R)/SgSn和B10.A(18R)/Sg。此外，还观察了大量经生理盐水处理的怀孕雌性小鼠所产仔鼠的腭裂频率。该对照组中的腭裂频率非常低，品系的排名与糖皮质激素诱导的腭裂频率相同。这一观察结果表明，诱导腭裂频率反映了这些品系中孤立性腭裂的自发发生率。
