Tyan M L, Tyan D B
West Los Angeles Veterans Affairs Medical Center, California.
Proc Soc Exp Biol Med. 1993 Apr;202(4):482-6. doi: 10.3181/00379727-202-43563.
Pregnant mice congenic with C57BL/10 in the region of H-2, the major histocompatibility complex on Chromosome 17 (B10.BR, B10.A, B10.A(1R), B10.A(2R), B10.A(15R), B10.A(18R), B10.OL, or crosses between them) were fed Purina Laboratory Chow or the same diet plus 400 IU of vitamin A daily from conception and given dexamethasone (80 or 160 mg/kg) intraperitoneally on the twelfth day of pregnancy. It was found that the added vitamin A increased the frequency of isolated cleft palate only in strains that had b alleles between C4 and B144. The enhancement of susceptibility to glucocorticosteroid-induced cleft palate by vitamin A appears to be a recessive trait and the locus, called Acp, maps centromeric to another corticosteroid-induced cleft palate gene (Dcp-2) that also is in the C4:B144 interval.
在H-2区域（位于17号染色体上的主要组织相容性复合体）与C57BL/10基因同源的怀孕小鼠（B10.BR、B10.A、B10.A(1R)、B10.A(2R)、B10.A(15R)、B10.A(18R)、B10.OL，或它们之间的杂交种）从受孕开始每天喂食普瑞纳实验室饲料或相同饲料加400国际单位维生素A，并在怀孕第12天腹腔注射地塞米松（80或160毫克/千克）。发现添加维生素A仅在C4和B144之间有b等位基因的品系中增加了孤立性腭裂的发生率。维生素A对糖皮质激素诱导腭裂易感性的增强似乎是一种隐性性状，该基因座称为Acp，定位于着丝粒方向，与另一个也在C4:B144区间的糖皮质激素诱导腭裂基因（Dcp-2）相邻。
