Larouzé B, Blumberg B S, London W T, Lustbader E D, Sankalé M, Payet M
J Natl Cancer Inst. 1977 Jun;58(6):1557-61. doi: 10.1093/jnci/58.6.1557.
An association between hepatitis B virus (HBV) and primary hepatocellular carcinoma (PHC) has been found in several studies in Africa, Asia, and elsewhere. In this paper we considered the interrelations between several events related to HBV infection, which include the presence of: 1) hepatitis B surface antigen (HBsAg), 2) antibody to hepatitis B core antigen (anti-HBc), 3) antibody to the surface antigen (anti-HBs), 4) chronic liver disease, 5) elevated alpha-fetoprotein, and 6) PHC. With the use of preliminary epidemiologic data, risk factors related to these events were calculated. We suggested that the interactions between these events and HBV infection in parents be used to estimate the risk of PHC for an individual in this environment.
在非洲、亚洲及其他地区的多项研究中，已发现乙肝病毒（HBV）与原发性肝细胞癌（PHC）之间存在关联。在本文中，我们探讨了与HBV感染相关的几个事件之间的相互关系，这些事件包括：1）乙肝表面抗原（HBsAg）的存在；2）乙肝核心抗原抗体（抗-HBc）；3）表面抗原抗体（抗-HBs）；4）慢性肝病；5）甲胎蛋白升高；6）原发性肝细胞癌。利用初步的流行病学数据，计算了与这些事件相关的风险因素。我们建议，利用这些事件与父母HBV感染之间的相互作用，来估计在这种环境下个体患原发性肝细胞癌的风险。
