Chestnut J S, Albin M S, Gonzalez-Abola E, Newfield P, Maroon J C
J Neurosurg. 1978 May;48(5):704-11. doi: 10.3171/jns.1978.48.5.0704.
Moment-to-moment control of blood pressure is important in the management of the neurosurgical patient. The ideal agent to control blood pressure or induce hypotension should be non-toxic, maintain cerebrovascular autoregulation, and not alter cardiac output or change intracranial pressure. Intravenous nitroglycerin has been used to control blood pressure in 54 neurosurgical cases. This agent produces a rapid, controllable, but not precipitous fall in blood pressure without rebound, is non-toxic, may not alter cerebrovascular autoregulation, and does not raise intracranial pressure. Our clinical experience with intravenous nitroglycerin indicates that it has an important role as a hypotensive agent for the neurosurgical patient.
血压的实时控制在神经外科患者的管理中至关重要。用于控制血压或诱导低血压的理想药物应无毒，维持脑血管自动调节功能，且不改变心输出量或颅内压。静脉注射硝酸甘油已用于54例神经外科病例的血压控制。该药物可使血压迅速、可控但非急剧下降且无反跳，无毒，可能不改变脑血管自动调节功能，也不升高颅内压。我们使用静脉注射硝酸甘油的临床经验表明，它作为神经外科患者的降压药物具有重要作用。
