Janbon F, Despaux E, Lepeu G, Jonquet O, Santoni A, Balmayer B, Bertrand A
Pathol Biol (Paris). 1982 Jun;30(6 Pt 2):563-7.
Fifty one cases of Pseudomonas aeruginosa bacteriaemia observed during the last 12 years are reported. Thirty five patients were over fifty years old; 92 p. cent were admitted for several days and about 50 p. cent were in post-operative period. A previous antibiotherapy and an impaired status are promotive factors. The respiratory or peritoneal origins are the most frequent. All patients were feverish; 24 have had an infectious shock which was inaugural in 12 cases. Seven pneumonitis, 3 endocarditis, one pericarditis and 2 osteitis were observed. An ecthyma gangrenosum was noted in three patients. Mortality was 70 p. cent. Comparison between recovered and died patients improved bad prognosis of old age, post operative period, neoplasic, previous organica weakness and pulmonary or peritoneal origins. Used alone, colimycin has seemed to be more effective than aminosid antibiotics; but their association with betalactamins was better. An in vitro study of the susceptibility of 100 Pseudomonas aeruginosa strains has proved the interest of piperacillin and cefsulodin; azlocillin, cefoperazone and ceftriaxone are just less effective.
报告了过去12年中观察到的51例铜绿假单胞菌菌血症病例。35例患者年龄超过50岁；92%的患者已住院数天，约50%的患者处于术后阶段。先前的抗生素治疗和身体状况受损是促进因素。呼吸道或腹膜来源最为常见。所有患者均发热；24例发生感染性休克，其中12例为首发。观察到7例肺炎、3例心内膜炎、1例心包炎和2例骨炎。3例患者出现坏疽性脓皮病。死亡率为70%。康复患者与死亡患者的比较显示，老年、术后阶段、肿瘤、先前的器质性虚弱以及肺部或腹膜来源的预后较差。单独使用时，黏菌素似乎比氨基糖苷类抗生素更有效；但它们与β-内酰胺类药物联合使用效果更好。对100株铜绿假单胞菌菌株的体外药敏研究证明了哌拉西林和头孢磺啶的有效性；阿洛西林、头孢哌酮和头孢曲松的有效性稍低。
