Iakushkina I V, Shapovalova S P, Malkova I V
Antibiotiki. 1982 Aug;27(8):601-7.
Antibacterial activity of 7 aminoglycoside antibiotics and combinations of tobramycin or gentamicin with carbenicillin was studied with respect to 33 clinical strains of Ps. aeruginosa. Tobramycin, sisomicin, gentamicin and amicacin showed high levels of antibacterial activity. Tobramycin and sisomicin were 3-4 and 2 times more effective than gentamicin. 100 per cent of the Ps. aeruginosa isolates was sensitive to tobramycin and amicacin. The number of the isolates sensitive to sisomicin and gentamicin amounted to 97 and 94 per cent respectively. The respective numbers for streptomycin and kanamycin were 32 and 11 per cent. No monomycin sensitive isolates were detected. Combination of tobramycin or gentamicin with carbenicillin increased the antibacterial activity of the aminoglycoside antibiotics by 2-16 times and that of carbenicillin by 2-32 times. The synergistic effect of gentamicin or tobramycin with carbenicilin was observed with respect to 50 and 58 per cent of the isolates respectively. No antagonistic effect was detected on the combined use of the antibiotics. The majority of the isolates (96 per cent) were sensitive to combinations of carbenicillin in a concentration of 50 micrograms/ml with tobramycin or gentamicin in concentrations of 0.15 or 0.3 micrograms/ml respectively.
针对33株铜绿假单胞菌临床菌株，研究了7种氨基糖苷类抗生素以及妥布霉素或庆大霉素与羧苄西林联合使用的抗菌活性。妥布霉素、西索米星、庆大霉素和阿米卡星显示出高水平的抗菌活性。妥布霉素和西索米星的有效性分别是庆大霉素的3 - 4倍和2倍。100%的铜绿假单胞菌分离株对妥布霉素和阿米卡星敏感。对西索米星和庆大霉素敏感的分离株数量分别为97%和94%。对链霉素和卡那霉素敏感的分离株数量分别为32%和11%。未检测到对单霉素敏感的分离株。妥布霉素或庆大霉素与羧苄西林联合使用使氨基糖苷类抗生素的抗菌活性提高了2 - 16倍，使羧苄西林的抗菌活性提高了2 - 32倍。庆大霉素或妥布霉素与羧苄西林联合使用分别对50%和58%的分离株显示出协同作用。未检测到抗生素联合使用的拮抗作用。大多数分离株（96%）对浓度为50微克/毫升的羧苄西林与浓度分别为0.15或0.3微克/毫升的妥布霉素或庆大霉素的联合制剂敏感。
