犬冠状动脉顺应性

Coronary artery compliance in the dog.

作者信息

Klassen G A, Wong A Y

出版信息

Can J Physiol Pharmacol. 1982 Jul;60(7):942-51. doi: 10.1139/y82-133.

Abstract

Measurement of left anterior descending coronary arterial pressure, phasic coronary flow, and intramyocardial pressure in an open-chest dog provided data, which when entered into the computer model of the coronary circulation, permitted calculation of coronary artery compliance and resistance during systole and diastole. Resting in vivo compliance averaged 0.21 x 10(-3) mL/mmHg (1 mmHg = 133.322 Pa) while systolic resistance averaged 4.05 mmHg X min-1 X mL-1 and during diastole 2.06 mmHg X min-1 X mL-1. Left stellate ganglion stimulation or vasodilation caused minimal changes in compliance but glutaraldehyde applied to arterial wall caused a decrease in compliance. Sympathetic stimulation and vasodilation decreased both diastolic and systolic resistance. Transmural distribution of coronary flow was not significantly altered by the experimental changes in compliance and resistance.

摘要

对开胸犬的左前降支冠状动脉压力、冠状动脉搏动血流以及心肌内压力进行测量，所获得的数据输入冠状动脉循环计算机模型后，可用于计算收缩期和舒张期冠状动脉的顺应性和阻力。静息状态下，体内顺应性平均为0.21×10⁻³ mL/mmHg（1 mmHg = 133.322 Pa），而收缩期阻力平均为4.05 mmHg·min⁻¹·mL⁻¹，舒张期为2.06 mmHg·min⁻¹·mL⁻¹。刺激左侧星状神经节或进行血管舒张，顺应性变化极小，但将戊二醛应用于动脉壁会导致顺应性降低。交感神经刺激和血管舒张可降低舒张期和收缩期阻力。顺应性和阻力的实验性变化并未显著改变冠状动脉血流的透壁分布。