Armour J A, Klassen G A
Can J Physiol Pharmacol. 1984 Jan;62(1):38-48. doi: 10.1139/y84-006.
Peripheral coronary venous pressures and coronary sinus venous flow were measured in the canine heart as well as intramyocardial, intraventricular, aortic, and coronary artery pressures. Maximum coronary venous flow occurred after maximum intramyocardial and peripheral coronary artery pressures had been reached. Maximum venous flow occurred at or following the maximum peripheral coronary vein pressure. Positive inotropic changes induced by stimulation of the right or left stellate ganglia or infusing isoproterenol, norepinephrine, or dobutamine significantly increased intramyocardial pressure, systolic epicardial coronary venous pressure, and systolic coronary venous flow. Mean coronary sinus flow was augmented by all interventions except isoproterenol. The estimated systolic vein resistance was slightly increased following right stellate ganglion stimulation, but not following left stellate ganglion stimulation, isoproterenol, or dobutamine. Norepinephrine reduced this parameter minimally. These data indicate that coronary veins respond differently to a variety of different positive inotropic interventions.
在犬类心脏中测量了外周冠状静脉压力和冠状窦静脉血流，以及心肌内、心室内、主动脉和冠状动脉压力。最大冠状静脉血流在达到最大心肌内和外周冠状动脉压力之后出现。最大静脉血流出现在外周冠状静脉压力最大值时或之后。刺激右侧或左侧星状神经节或输注异丙肾上腺素、去甲肾上腺素或多巴酚丁胺引起的正性肌力变化显著增加了心肌内压力、收缩期心外膜冠状静脉压力和收缩期冠状静脉血流。除异丙肾上腺素外，所有干预措施均增加了冠状窦平均血流。右侧星状神经节刺激后，估计的收缩期静脉阻力略有增加，但左侧星状神经节刺激、异丙肾上腺素或多巴酚丁胺刺激后未增加。去甲肾上腺素对该参数的降低作用最小。这些数据表明，冠状静脉对各种不同的正性肌力干预反应不同。
