James D W, Ludvigsen N W, Cleland L G, Milazzo S C
J Rheumatol. 1982 Jul-Aug;9(4):532-5.
Plasma and erythrocyte gold concentrations were measured in 35 patients taking gold sodium thiomalate (GSTM) for rheumatoid arthritis. In 6 patients with adverse effects attributable to gold therapy at the time of sampling, gold concentrations in plasma and erythrocyte fractions were no different from those without adverse effects. A significant difference was seen in the distribution of gold in the blood of cigarette smokers compared to non-smokers, with smokers having higher erythrocyte and lower plasma gold concentrations. A prospective study on 15 patients commencing treatment with GSTM showed that the higher concentrations of erythrocyte gold seen in smokers were achieved within the first 2 weeks of treatment.
对35名服用硫代苹果酸金钠（GSTM）治疗类风湿性关节炎的患者进行了血浆和红细胞金浓度测定。在采样时6名有金疗法不良反应的患者中，血浆和红细胞部分的金浓度与无不良反应的患者无差异。与不吸烟者相比，吸烟者血液中金子的分布有显著差异，吸烟者红细胞金浓度较高，血浆金浓度较低。一项对15名开始用GSTM治疗的患者的前瞻性研究表明，吸烟者红细胞金浓度较高的情况在治疗的前2周内就出现了。
