[Induction of ovulation and pregnancy resulting from chronic and pulsatile administration of gonadotropin-releasing-hormone (Gn-RH)].

Amenorrhoea of high origin, namely hypothalamic, reflects inhibition or a drop in endogenous secretion of Gn-RH. Two patients with this trouble were treated with synthetic Gn-RH in a pulsatile way and by a continuous method. We have been using a portable reprogrammable mini-pump (Zyklomat-Ferring) connected up to an intravenous catheter which has delivered 15 to 20 micrograms of Gn-RH for one minute every 90 minutes. This treatment brought about progressive rises in serum concentrations of oestradiol and of LH. The ovulation was obtained in both women, and checked by the demonstration by ultra-sound of rupture of the dominant follicle and by estimation of plasma and progesterone levels. One of them became pregnant following this treatment. This kind of therapy seems to us to be an attractive physiological alternative for induction of ovulation.