Ropert J F, Gaillard G, Doly M, Bruhat M A
J Gynecol Obstet Biol Reprod (Paris). 1982;11(4):505-8.
Amenorrhoea of high origin, namely hypothalamic, reflects inhibition or a drop in endogenous secretion of Gn-RH. Two patients with this trouble were treated with synthetic Gn-RH in a pulsatile way and by a continuous method. We have been using a portable reprogrammable mini-pump (Zyklomat-Ferring) connected up to an intravenous catheter which has delivered 15 to 20 micrograms of Gn-RH for one minute every 90 minutes. This treatment brought about progressive rises in serum concentrations of oestradiol and of LH. The ovulation was obtained in both women, and checked by the demonstration by ultra-sound of rupture of the dominant follicle and by estimation of plasma and progesterone levels. One of them became pregnant following this treatment. This kind of therapy seems to us to be an attractive physiological alternative for induction of ovulation.
高位性闭经，即下丘脑性闭经，反映了内源性促性腺激素释放激素（Gn-RH）分泌受到抑制或下降。两名患有这种病症的患者分别接受了脉冲式和连续式合成Gn-RH治疗。我们使用了一种便携式可重新编程微型泵（Zyklomat - Ferring），它与一根静脉导管相连，每90分钟输送15至20微克Gn-RH，持续一分钟。这种治疗使血清雌二醇和促黄体生成素（LH）浓度逐渐升高。两名女性均实现了排卵，通过超声显示优势卵泡破裂以及检测血浆和孕酮水平进行了确认。其中一名女性在接受此治疗后怀孕。在我们看来，这种疗法似乎是诱导排卵的一种有吸引力的生理性替代方法。
