Krafft K, Lyon D O, Poling A
Psychopharmacology (Berl). 1982;78(1):93-5. doi: 10.1007/BF00470597.
The present study examined the effects of acute administrations of phenytoin on the lever pressing of rats maintained under fixed-ratio, fixed-interval, and interresponse-time-greater-than-T schedules of food delivery. The drug typically produced dose-dependent decreases in response rates under fixed-ratio and fixed-interval schedules, while response rates under the interresponse-time-greater-than-T schedule were affected little by the drug. These findings indicate that phenytoin effects on schedule-controlled responding differ from those of other anticonvulsants.
本研究考察了急性给予苯妥英对按固定比率、固定间隔和反应时间大于T的食物投递时间表维持的大鼠杠杆按压行为的影响。在固定比率和固定间隔时间表下，该药物通常会使反应率产生剂量依赖性下降，而在反应时间大于T的时间表下，反应率受该药物的影响很小。这些发现表明，苯妥英对时间表控制反应的影响与其他抗惊厥药物不同。
