胎鼠前胰岛的分离与移植。

The isolation and transplantation of foetal mouse proislets.

作者信息

Simeonovic C J, Lafferty K J

出版信息

Aust J Exp Biol Med Sci. 1982 Aug;60 Pt 4:383-90. doi: 10.1038/icb.1982.42.

DOI:10.1038/icb.1982.42

Abstract

A method is described for the isolation of "proislets' from mouse foetal pancreas. Histologically, isolated proislets are composed of undifferentiated tissue which does not stain with aldehyde fuchsin. Following isotransplantation, proislets develop into well differentiated islets with beta cell granulation. In addition, isografts consisting of proislets harvested from 8 foetal mouse pancreases have the functional capacity to reverse Streptozotocin-induced diabetes. Proislets appear to represent foetal precursor islet tissue.

摘要

本文描述了一种从小鼠胎儿胰腺中分离“前胰岛”的方法。从组织学上看，分离出的前胰岛由未分化组织组成，该组织不能被醛品红染色。同种移植后，前胰岛发育成具有β细胞颗粒的高度分化的胰岛。此外，由8个胎儿小鼠胰腺收获的前胰岛组成的同基因移植物具有逆转链脲佐菌素诱导的糖尿病的功能能力。前胰岛似乎代表胎儿期胰岛前体组织。