DNA合成的抑制并不影响梨形四膜虫中H1组蛋白的合成。

Inhibition of DNA synthesis does not influence the H1 histone synthesis in Tetrahymena pyriformis.

作者信息

Klenow S

出版信息

Biochim Biophys Acta. 1982 Oct 29;699(1):49-52. doi: 10.1016/0167-4781(82)90170-1.

Abstract

In the protozoan Tetrahymena pyriformis the DNA synthesis is stopped immediately and completely after addition of one of the two DNA synthesis inhibitors methotrexate + uridine and hydroxyurea to a cell suspension. However, the present experiments show, that the accumulation of labeled H1 histone in the inhibited cells is almost totally unaffected for more than two-thirds of a cell cycle after addition of either inhibitor.

摘要

在梨形四膜虫中，向细胞悬液添加两种DNA合成抑制剂之一甲氨蝶呤+尿苷或羟基脲后，DNA合成会立即且完全停止。然而，目前的实验表明，添加任何一种抑制剂后，在超过三分之二个细胞周期的时间里，受抑制细胞中标记的H1组蛋白的积累几乎完全不受影响。