Kelly J F, Patterson R, Lieberman P, Mathison D A, Stevenson D D
J Allergy Clin Immunol. 1978 Sep;62(3):181-4. doi: 10.1016/0091-6749(78)90104-5.
Patients with prior anaphylactoid reactions (AR) to radiographic contrast media (RCM) are at increased risk for another reaction upon repeat exposure to RCM. One hundred one patients, who had prior AR to RCM, who gave informed consent, and who had an essential need for a repeat RCM study, were pretreated with prednisone, 50 mg orally every 6 hours for 3 doses ending one hour prior to RCM study, and diphenhydramine, 50 mg intramuscularly, one hour prior to RCM study. The repeat RCM study was then carried out using standard procedures with resuscitation equipment readily available. Ninety-six patients had no reaction. Five of the 101 (4.95%) developed AR. These AR consisted only of mild urticaria or pruritus. No significant or life-threatening reactions occurred. Pretreatment decreases the risk in this population of patients and is recommended as standard prophylaxis for patients requiring RCM who have had a previous AR.
既往对放射造影剂（RCM）有类过敏反应（AR）的患者在再次接触RCM时发生另一次反应的风险会增加。101例既往对RCM有AR、签署了知情同意书且确实需要重复进行RCM检查的患者，在RCM检查前1小时接受泼尼松预处理，口服50mg，每6小时1次，共3剂，以及在RCM检查前1小时肌肉注射苯海拉明50mg。然后使用标准程序进行重复RCM检查，并随时准备好复苏设备。96例患者未出现反应。101例中有5例（4.95%）发生了AR。这些AR仅表现为轻度荨麻疹或瘙痒。未发生严重或危及生命的反应。预处理可降低该患者群体的风险，对于既往有AR且需要RCM的患者，建议将其作为标准预防措施。
