Henriksen L, Paulson O B
Eur J Clin Invest. 1982 Oct;12(5):389-93. doi: 10.1111/j.1365-2362.1982.tb00685.x.
Cerebral blood flow (CBF) and cerebral venous blood gases were investigated in seven awake patients during hypotension induced with sodium nitroprusside. Infusion of the drug into the internal carotid artery produced no changes in cerebral haemodynamics. Intravenous nitroprusside infusion resulted in a decrease in both CBF and jugular venous PO2 (P less than 0.01, respectively). Reducing mean arterial blood pressure by 18% and 43% produced a mean CBF fall of 6% and 27% respectively. Arteriovenous oxygen difference increased in consonance with the CBF decrease (P less than 0.01). Arterial PCO2 fell during the infusion (P less than 0.01). At 18% blood pressure reduction, the observed PCO2 decrease of 0.25 kPa could account for the 6% CBF decrease. At 43% blood pressure reduction, PCO2 fell by 0.53 kPa, a decrease which could not explain the observed CBF fall of 27%. Dizziness and incipient fainting occurred in the patients at this point. It is concluded that sodium nitroprusside has a minor but significant effect on cerebral haemodynamics in normal awake man.
在七名清醒患者中，研究了硝普钠诱导低血压期间的脑血流量（CBF）和脑静脉血气。将药物注入颈内动脉对脑血流动力学无影响。静脉输注硝普钠导致CBF和颈静脉PO2均下降（P分别小于0.01）。平均动脉血压降低18%和43%时，CBF平均分别下降6%和27%。动静脉氧差随CBF下降而增加（P小于0.01）。输注期间动脉PCO2下降（P小于0.01）。血压降低18%时，观察到的PCO2下降0.25 kPa可解释CBF下降6%。血压降低43%时，PCO2下降0.53 kPa，这一下降无法解释观察到的CBF下降27%。此时患者出现头晕和早期昏厥。结论是硝普钠对正常清醒人的脑血流动力学有轻微但显著的影响。
