免疫球蛋白基因的等位基因排斥和同种型排斥理论。
A theory of allelic and isotypic exclusion for immunoglobulin genes.
作者信息
Wabl M, Steinberg C
出版信息
Proc Natl Acad Sci U S A. 1982 Nov;79(22):6976-8. doi: 10.1073/pnas.79.22.6976.
Abstract
Heavy (H) chain binding protein (BiP), which binds to free immunoglobulin H chain of the mu and gamma classes, can be demonstrated in pre-B-cells. It is proposed that the displacement of BiP from H chain by light (L) chain terminates the activity of the enzyme system, L-generase, which catalyzes DNA rearrangement at the L chain loci, generating the complete gene which may or may not be functional. This ensures allelic and isotypic exclusion for the L chain loci. It is further proposed that those cells that productively rearrange both alleles at the H chain locus are eliminated by the "H chain toxicity" effect.
摘要
重链结合蛋白（BiP）可与μ和γ类别的游离免疫球蛋白重链结合，在前B细胞中可以检测到它。有人提出，轻链（L链）将BiP从H链上置换下来会终止酶系统L-生成酶的活性，该酶系统催化轻链基因座处的DNA重排，产生可能有功能或可能无功能的完整基因。这确保了轻链基因座的等位基因排斥和同种型排斥。还提出，那些在重链基因座上两个等位基因都有效重排的细胞会因“重链毒性”效应而被清除。
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