Willcox P A, Benatar S R, Potgieter P D
Thorax. 1982 Aug;37(8):598-601. doi: 10.1136/thx.37.8.598.
In four years' use of the flexible fibreoptic bronchoscope in diagnosing sputum-negative pulmonary tuberculosis, of 275 patients with tuberculosis suspected from chest radiographic appearances, 89 (32.4%) were shown to have active disease. In 60 (67.4%) of these patients the diagnosis was made from samples obtained through the fibreoptic bronchoscope (56 from bronchial brushings, four from transbronchial biopsy samples). Of the 56 positive bronchial brushings, 35 were positive on direct smear and 21 only on culture. Transbronchial biopsy exclusively accounted for only four of the 60 positive diagnoses. In the remaining 29 patients, the diagnosis was made from further sputum or biopsy specimens in 15, from the response to treatment in 12, and at necropsy in two. In six of 10 patients with military tuberculosis, bronchial brushings were positive on direct smear.
在使用可弯曲纤维支气管镜诊断痰菌阴性肺结核的四年中，对275例根据胸部X线表现怀疑患有结核病的患者进行检查，其中89例（32.4%）被证实患有活动性疾病。在这些患者中，60例（67.4%）的诊断是通过纤维支气管镜获取的样本做出的（56例来自支气管刷检，4例来自经支气管活检样本）。在56例支气管刷检阳性病例中，35例直接涂片阳性，21例仅培养阳性。经支气管活检仅占60例阳性诊断中的4例。在其余29例患者中，15例通过进一步的痰液或活检标本确诊，12例根据治疗反应确诊，2例通过尸检确诊。在10例粟粒性肺结核患者中，有6例支气管刷检直接涂片呈阳性。
