Alexandrov K, Becker M, Frayssinet C, Dubowska W, Guerry R
Cancer Lett. 1982 Sep;16(3):247-51. doi: 10.1016/0304-3835(82)90003-9.
The covalently bound products of [3H]benzo[alpha]pyrene (BP) were determined in the DNA isolated from the skin of mice 3 weeks after application of the carcinogen. In the relatively rapidly proliferating skin the persistence of BP-DNA adducts was observed, 50% of which were unmodified nucleosides. Small amounts of (7R) BPDE I-dG adduct (5% from the initial formation) were found after 3 weeks. The minor adducts observed at 18 h after treatment were excised.
在施用致癌物3周后，从小鼠皮肤分离的DNA中测定了[3H]苯并[a]芘（BP）的共价结合产物。在增殖相对较快的皮肤中观察到BP-DNA加合物的持续存在，其中50%是未修饰的核苷。3周后发现少量（7R）BPDE I-dG加合物（占初始形成量的5%）。处理后18小时观察到的次要加合物被切除。
