Hamill P V, Steinberger E, Levine R J, Rodriguez-Rigau L J, Lemeshow S, Avrunin J S
J Occup Med. 1982 Dec;24(12):985-93.
Dinitrotoluene (DNT) and toluene diamine (TDA) are intermediates in the production of toluene diisocyanate and polyurethane plastics. Some reproductive effects in rodents have been reported; and the National Institute for Occupational Safety and Health reported probable reproductive toxic effect to humans after a preliminary survey. Accordingly, 84 workers exposed to DNT/TDA (classified by intensity and recency of exposure) and 119 nonexposed workers were studied at Olin's chemical complex at Lake Charles, La. Each worker was the subject of a physician's urogenital examination, a reproductive and fertility questionnaire, an estimation of testicular volume, an assessment of serum follicle-stimulating hormone, and an analysis of semen for sperm count and morphology. No differences were found between the exposed and control groups among any of these variables. Although both TDA and DNT are readily absorbed (percutaneous, inhalation, ingestion), they did not present detectable reproductive hazard to the workers.
二硝基甲苯（DNT）和甲苯二胺（TDA）是生产甲苯二异氰酸酯和聚氨酯塑料的中间体。据报道，它们对啮齿动物有一些生殖方面的影响；美国国家职业安全与健康研究所经过初步调查后报告称，其对人类可能具有生殖毒性作用。因此，在路易斯安那州查尔斯湖的奥林化学工厂，对84名接触DNT/TDA的工人（根据接触强度和近期接触情况分类）以及119名未接触的工人进行了研究。每位工人都接受了医生的泌尿生殖系统检查、生殖与生育问卷调查、睾丸体积评估、血清促卵泡激素测定以及精液的精子计数和形态分析。在这些变量中，暴露组和对照组之间未发现差异。尽管TDA和DNT都易于被吸收（经皮、吸入、摄入），但它们并未对工人造成可检测到的生殖危害。
