Whorton M D, Milby T H, Stubbs H A, Avashia B H, Hull E Q
J Toxicol Environ Health. 1979 Sep;5(5):929-41. doi: 10.1080/15287397909529802.
A cohort of 101 male carbaryl production workers with at least 1 yr experience in the carbaryl area was selected from employment records. Of these individuals, 47 provided satifactory semen samples for analysis; 36 of the 47 provided blood for hormone assay. There were no major age or employment-status differences between those who agreed to participate and those who did not. In the absence of sufficiently detailed industrial hygiene exposure data, a subjective exposure classification was developed. No apparent relationships were found between sperm count and exposure category or years worked in classifications based on carbaryl exposure. Also, no relationship was found between fathering children and exposure to carbaryl. When the sperm-count distribution of the carbaryl-exposed workers was compared with a distribution of sperm counts representing a nonexposed (control) population, no overall differences were observed that could be related to carbaryl exposure. There was a small excess in the number of sperm counts less than 20 million per milliliter among the carbaryl-exposed men, but the excess was not significant at alpha = 0.05.
从就业记录中选取了101名在西维因生产领域至少有1年工作经验的男性工人组成一个队列。在这些人中，47人提供了合格的精液样本用于分析；这47人中的36人提供了血液用于激素检测。同意参与的人和不同意参与的人在年龄或就业状况方面没有重大差异。由于缺乏足够详细的工业卫生暴露数据，制定了一种主观暴露分类方法。在基于西维因暴露的分类中，未发现精子计数与暴露类别或工作年限之间存在明显关系。此外，未发现生育子女与西维因暴露之间存在关系。当将接触西维因的工人的精子计数分布与代表未接触（对照）人群的精子计数分布进行比较时，未观察到与西维因暴露相关的总体差异。接触西维因的男性中，每毫升精子计数低于2000万的数量略有增加，但在α = 0.05时，这种增加并不显著。
