Nomura Y, Oki K
Pharmacol Biochem Behav. 1980 Jun;12(6):925-30. doi: 10.1016/0091-3057(80)90454-2.
The behavioral effect of thyrotropin releasing hormone (TRH) was investigated in the developing rat pretreated with 6-OHDOPA at birth. An IP injection of TRH (20 mg/kg) increased walking with sniffing, rearing, body shaking, grooming, chewing and licking in the 7-, 14-, 20- and 30-day-old as well as in the adult rat. TRH-induced locomotor stimulation began a few minutes after the injection and lasted for approximately 60 min. But on Day 7, TRH produced locomotor stimulation betwen 1.5 hr and 3.5 hr after the injection. Neonatal treatment with 6-OHDOPA markedly potentiated TRH-induced locomotor stimulation and behavioral arousal in the 7-day-old rat but not in the 14-day-old and adult rat. The marked potentiation of TRH-induced locomotor stimulation by 6-OHDOPA in the 7-day-old rat was reduced by alpha-flupenthixol (pA2=5.9) and phenoxybenzamine (pA2=4.4). These results suggest that central dopamine neurons are involved in TRH-induced behavioral arousal in the infant rat.
研究了出生时用6-羟基多巴胺预处理的发育中大鼠促甲状腺激素释放激素（TRH）的行为效应。腹腔注射TRH（20毫克/千克）可增加7日龄、14日龄、20日龄、30日龄大鼠以及成年大鼠的嗅探行走、竖毛、身体抖动、梳理、咀嚼和舔舐行为。TRH诱导的运动刺激在注射后几分钟开始，持续约60分钟。但在7日龄时，TRH在注射后1.5小时至3.5小时产生运动刺激。新生期用6-羟基多巴胺处理显著增强了7日龄大鼠TRH诱导的运动刺激和行为觉醒，但对14日龄大鼠和成年大鼠无此作用。7日龄大鼠中6-羟基多巴胺对TRH诱导的运动刺激的显著增强作用被α-氟哌噻吨（pA2 = 5.9）和酚苄明（pA2 = 4.4）减弱。这些结果表明，中枢多巴胺神经元参与了幼鼠TRH诱导的行为觉醒。
