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右旋苯丙胺和光照对大鼠固定间隔反应影响的年龄相关差异。

Age-related differences in the effects of d-amphetamine and illumination on fixed-interval responding of rats.

作者信息

Delay E R

出版信息

Psychopharmacology (Berl). 1982;78(3):298-9. doi: 10.1007/BF00428171.

DOI:10.1007/BF00428171
PMID:6818586
Abstract

The effects of d-amphetamine (0.0, 0.4, and 0.8 mg/kg) on fixed-interval responding in light and dark sensory conditions were examined in rats that were 25, 100, and 200-days-old at the beginning of the experiment. In the youngest and oldest groups, the drug increased responding in light more than in dark. The drug increased responding of the middle age group in the light, but decreased operant rates in the dark. These data appear to support the notion that d-amphetamine reduces the effects of ambient light on behavior in rats.

摘要

在实验开始时分别为25日龄、100日龄和200日龄的大鼠中,研究了右旋苯丙胺(0.0、0.4和0.8毫克/千克)对明暗两种感觉条件下固定间隔反应的影响。在最年幼和最年长的组中,该药物对光照条件下反应的增强作用大于黑暗条件。该药物增加了中年组在光照条件下的反应,但降低了其在黑暗条件下的操作率。这些数据似乎支持了右旋苯丙胺可降低环境光对大鼠行为影响的观点。

相似文献

1
Age-related differences in the effects of d-amphetamine and illumination on fixed-interval responding of rats.右旋苯丙胺和光照对大鼠固定间隔反应影响的年龄相关差异。
Psychopharmacology (Berl). 1982;78(3):298-9. doi: 10.1007/BF00428171.
2
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本文引用的文献

1
A study of the relationship between the visual system and the effects of d-amphetamine.一项关于视觉系统与右旋苯丙胺作用之间关系的研究。
Physiol Behav. 1971 Feb;6(2):157-9. doi: 10.1016/0031-9384(71)90084-9.
2
The effects of d- and l- amphetamine on fixed-interval and fixed-ratio behavior in tolerant and nontolerant rats.
J Pharmacol Exp Ther. 1973 Nov;187(2):372-9.
3
The effects of age and illumination on the dose-response curves for three stimulants.
Psychopharmacologia. 1975;40(4):313-8. doi: 10.1007/BF00421469.