右旋苯丙胺对大鼠固定间隔时间表行为影响的分子分析。
Molecular analyses of the effects of d-amphetamine on fixed-interval schedule performances of rats.
作者信息
McAuley F, Leslie J C
出版信息
J Exp Anal Behav. 1986 Mar;45(2):207-19. doi: 10.1901/jeab.1986.45-207.
Abstract
A series of doses (0.5 to 2.0 mg/kg) of d-amphetamine was administered to rats whose lever pressing was maintained by fixed-interval 30-s, 60-s, or 120-s schedules of reinforcement by sucrose delivery. Under both saline and d-amphetamine conditions, molecular features of responding were reliably described in terms of the distribution of postreinforcement pauses and local response rate following the onset of responding. Postreinforcement pause always varied from interval to interval but, on average, shortened under the drug. Local response rate (response rate exclusive of pause time) tended to decrease under the drug, and where acceleration occurred within runs of responses, it was reduced by the drug. All of these effects were dose-related. These findings suggest that fixed-interval behavior can be analyzed effectively at a molecular level, and that the effects of d-amphetamine are best described as disruption of temporal discrimination.
摘要
将一系列剂量（0.5至2.0毫克/千克）的右旋苯丙胺给予大鼠，这些大鼠通过固定间隔30秒、60秒或120秒的蔗糖递送强化程序来维持杠杆按压。在生理盐水和右旋苯丙胺条件下，根据强化后停顿的分布以及反应开始后的局部反应率，能够可靠地描述反应的分子特征。强化后停顿总是因间隔不同而变化，但平均而言，在药物作用下会缩短。局部反应率（不包括停顿时间的反应率）在药物作用下往往会降低，并且在反应序列中出现加速时，药物会使其降低。所有这些效应都与剂量相关。这些发现表明，固定间隔行为可以在分子水平上进行有效分析，并且右旋苯丙胺的作用最好描述为对时间辨别能力的破坏。
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2
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3
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