Ioannides C, Stone A N, Breacker P J, Basu T K
Biochem Pharmacol. 1982 Dec 15;31(24):4035-8. doi: 10.1016/0006-2952(82)90652-9.
A study was undertaken to investigate the interactions between aspirin and ascorbic acid in guinea pigs. Animals received by gastric intubation either a single dose of radiolabelled ascorbic acid alone or ascorbic acid with aspirin and the exhalation of CO2 was monitored for 400 min following administration. Animals receiving the vitamin only reached plasma peak levels within 90 min following administration while coadministration of the vitamin with aspirin, not only resulted in lower plasma peak levels, but also delayed their attainment until after 160 min. The bioavailability of ascorbic acid during the first 400 min was reduced by half following simultaneous administration of aspirin. The initial rate of exhalation of CO2 was decreased by 70% following coadministration of aspirin. These observations indicate that aspirin impairs the gastrointestinal absorption of ascorbic acid in guinea pigs, possibly by interfering with its active transport.
进行了一项研究，以调查豚鼠体内阿司匹林和抗坏血酸之间的相互作用。通过胃插管给动物单独给予单剂量放射性标记的抗坏血酸，或给予抗坏血酸与阿司匹林，给药后监测400分钟内二氧化碳的呼出情况。仅接受维生素的动物在给药后90分钟内达到血浆峰值水平，而维生素与阿司匹林共同给药时，不仅导致血浆峰值水平较低，而且延迟至160分钟后才达到峰值。同时给予阿司匹林后，抗坏血酸在最初400分钟内的生物利用度降低了一半。阿司匹林共同给药后，二氧化碳的初始呼出速率降低了70%。这些观察结果表明，阿司匹林可能通过干扰抗坏血酸的主动转运，损害豚鼠胃肠道对其的吸收。
