Basu T K
Int J Vitam Nutr Res Suppl. 1982;23:83-90.
The effect of soluble aspirin on the availability of vitamin C has been studied in guinea-pigs and human subjects. In the human study, the concentrations of vitamin C in plasma, leucocytes and urine were found to be markedly elevated at various intervals following administration of a single oral dose of 500 mg of the vitamin. The vitamin C-associated increases, however, appeared to be blocked when the vitamin was given simultaneously with aspirin (900 mg). Similar findings were observed in guinea-pigs, where in addition faecal excretion of vitamin C was found to be significantly increased when the vitamin was administered together with aspirin. These results suggest that aspirin may impede gastrointestinal absorption of vitamin C. This hypothesis has been strengthened with in vitro studies using everted gut sac preparations where both the serosal/mucosal concentration gradient and the uptake of vitamin C per unit weight of intestine were markedly lowered by acetyl-salicylate. Such an interaction is relevant to the population where vitamin C intake is borderline.
已在豚鼠和人体中研究了可溶性阿司匹林对维生素C可用性的影响。在人体研究中，单次口服500毫克维生素后，在不同时间间隔发现血浆、白细胞和尿液中的维生素C浓度显著升高。然而，当维生素与阿司匹林（900毫克）同时给药时，维生素C相关的增加似乎受到了阻碍。在豚鼠中也观察到了类似的结果，当维生素与阿司匹林一起给药时，维生素C的粪便排泄量也显著增加。这些结果表明阿司匹林可能会阻碍维生素C的胃肠道吸收。使用外翻肠囊制剂进行的体外研究进一步证实了这一假设，在该研究中，乙酰水杨酸显著降低了浆膜/粘膜浓度梯度以及单位重量肠道对维生素C的摄取。这种相互作用与维生素C摄入量处于临界水平的人群有关。
