Cannella G, Cancarini G, De Marinis S, Maccagnola V, Tosoni S, Cristinelli L, Maiorca R
Int J Artif Organs. 1982 Nov;5(6):357-60.
To determine to what extent the intradialysis changes in blood pressure (BP) are related to the variations in blood gases and plasma acetate concentrations (plAc), 11 dialysed uremics were studied with measurement of plAc,pH, pCO2 and pO2 every 60' during a hemodialysis lasting 4 hrs. Dialysis resulted in significant decreases in the BP, pO2 and pCO2 and in significant increases in pH and plAc. Multiple regression analysis demonstrated that the delta % for the mean BP was closely related to plAc, pCO2 and delta-% of body weight (BW). Partial regression coefficient indicated the following rank order of correlation: plAc greater than pCO2 greater than or equal to delta-% BW greater than pO2 = O, thus demonstrating that the fall in blood pressure is related both to the increase in plAc and the decrease in pCO2. The physiological relevance of these relationships is discussed. The hypothesis is advanced that the pCO2 decrease during dialysis might contribute to the acetate-induced vascular instability.
为了确定透析过程中血压（BP）的变化在多大程度上与血气和血浆醋酸盐浓度（plAc）的变化相关，我们对11名接受透析的尿毒症患者进行了研究，在持续4小时的血液透析过程中，每60分钟测量一次plAc、pH、pCO2和pO2。透析导致血压、pO2和pCO2显著下降，pH和plAc显著升高。多元回归分析表明，平均血压的变化百分比（delta %）与plAc、pCO2和体重（BW）变化百分比密切相关。偏回归系数表明了以下相关程度排序：plAc大于pCO2大于或等于BW变化百分比大于pO2 = 0，从而表明血压下降既与plAc升高有关，也与pCO2降低有关。本文讨论了这些关系的生理相关性。我们提出一个假设，即透析过程中pCO2降低可能导致醋酸盐诱导的血管不稳定。
