Ridsdale L, Moseley I
J Neurol Neurosurg Psychiatry. 1978 Aug;41(8):737-45. doi: 10.1136/jnnp.41.8.737.
Five patients are described in whom a benign or malignant thoracolumbar tumour, producing increased level of cerebrospinal fluid protein, was associated with hydrocephalus or papilloedema or both. A review of the clinical and laboratory features in these and 40 published cases underlines the difficulty in explaining the increased intracranial pressure in such patients. Slow absorption of cerebrospinal fluid as a result of the elevated protein levels or recurrent subarachnoid bleeding may play a part. When patients are discovered to have communicating hydrocephalus or a syndrome resemlbing benign intracranial hypertension, the finding of increased cerebrospinal fluid protein or any symptoms or signs relative to the spine should suggest the possibility of an intraspinal tumour.
本文描述了5例胸腰椎良性或恶性肿瘤患者,这些肿瘤导致脑脊液蛋白水平升高,并伴有脑积水或视乳头水肿,或两者兼有。对这些患者以及40例已发表病例的临床和实验室特征进行回顾后发现,解释此类患者颅内压升高存在困难。蛋白水平升高导致脑脊液吸收缓慢或反复蛛网膜下腔出血可能起到了一定作用。当发现患者患有交通性脑积水或类似良性颅内高压的综合征时,脑脊液蛋白升高或任何与脊柱相关的症状或体征都应提示存在脊柱内肿瘤的可能性。