Banford J C, Brown D H, Hazelton R A, McNeil C J, Smith W E, Sturrock R D
Rheumatol Int. 1982;2(3):107-11. doi: 10.1007/BF00541162.
The thiol status of patients with rheumatoid arthritis is significantly different from that of controls. Plasma thiol levels are lower, albumin thiol reactivity is altered and intracellular thiol levels measured after hemoglobin precipitation are increased. These variations correlate with other indices of disease severity and are one measure of a disturbance in the degree of oxidation of the blood. Penicillamine, in common with other effective therapeutic agents, produces an increase in serum thiol concentration. It causes a greater effect on serum thiol reactivity than other drugs and in particular it increases 'fast reacting' thiol levels without significantly altering the 'slow reacting' thiol level.
类风湿性关节炎患者的硫醇状态与对照组显著不同。血浆硫醇水平较低，白蛋白硫醇反应性改变，血红蛋白沉淀后测得的细胞内硫醇水平升高。这些变化与疾病严重程度的其他指标相关，是血液氧化程度紊乱的一种度量。青霉胺与其他有效治疗药物一样，会使血清硫醇浓度升高。它对血清硫醇反应性的影响比其他药物更大，特别是它会增加“快速反应”硫醇水平，而不会显著改变“缓慢反应”硫醇水平。
