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[大鼠脑片去极化后γ-羟基丁酸的钙依赖性释放]

[Calcium-dependent liberation of gamma-hydroxybutyrate after depolarization of rat brain slices].

作者信息

Maitre M, Mandel P

出版信息

C R Seances Acad Sci III. 1982 Dec 6;295(12):741-3.

PMID:6820307
Abstract

The release of gamma-hydroxybutyrate from preloaded Rat brain striatal slices was investigated. Potassium induced depolarisation caused an efflux of gamma-hydroxybutyrate in the incubation medium. This release is significantly decreased by a calcium free medium, containing magnesium salt and EGTA. Taking into account our previous results concerning synthesis, uptake and binding of gamma-hydroxybutyrate, this calcium-dependent release strongly suggest a possible role of gamma-hydroxybutyrate in neurotransmission in the C.N.S.

摘要

研究了预先加载的大鼠脑纹状体切片中γ-羟基丁酸的释放情况。钾诱导的去极化导致γ-羟基丁酸在孵育培养基中流出。在含有镁盐和乙二醇双四乙酸（EGTA）的无钙培养基中，这种释放显著减少。考虑到我们之前关于γ-羟基丁酸的合成、摄取和结合的研究结果，这种钙依赖性释放强烈表明γ-羟基丁酸在中枢神经系统神经传递中可能发挥作用。

相似文献

1
[Calcium-dependent liberation of gamma-hydroxybutyrate after depolarization of rat brain slices].[大鼠脑片去极化后γ-羟基丁酸的钙依赖性释放]
C R Seances Acad Sci III. 1982 Dec 6;295(12):741-3.
2
Depolarization-evoked release of gamma-hydroxybutyrate from rat brain slices.去极化诱发大鼠脑片释放γ-羟基丁酸
J Neurochem. 1983 Jul;41(1):287-90. doi: 10.1111/j.1471-4159.1983.tb11843.x.
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gamma-Hydroxybutyrate uptake by rat brain striatal slices.大鼠脑纹状体切片对γ-羟基丁酸的摄取
Neurochem Res. 1985 Mar;10(3):387-96. doi: 10.1007/BF00964607.
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[Properties allowing the attribution to gamma-hydroxybutyrate the quality of neurotransmitter in the central nervous system].[使γ-羟基丁酸具备中枢神经系统神经递质性质的特性]
C R Acad Sci III. 1984;298(12):341-5.
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Regional differences in depolarization-induced release of gamma-hydroxybutyrate from rat brain slices.大鼠脑片去极化诱导的γ-羟基丁酸释放的区域差异。
Neurosci Lett. 1988 Apr 22;87(1-2):99-103. doi: 10.1016/0304-3940(88)90152-8.
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Effect of anticonvulsant drugs on gamma-hydroxybutyrate release from hippocampal slices: inhibition by valproate and ethosuximide.抗惊厥药物对海马切片中γ-羟基丁酸释放的影响：丙戊酸盐和乙琥胺的抑制作用。
J Neurochem. 1987 Oct;49(4):1022-4. doi: 10.1111/j.1471-4159.1987.tb09989.x.
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Localization studies of gamma-hydroxybutyrate receptors in rat striatum and hippocampus.大鼠纹状体和海马中γ-羟基丁酸受体的定位研究。
Brain Res Bull. 1989 Jul-Aug;23(1-2):129-35. doi: 10.1016/0361-9230(89)90171-8.
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Release of monoamines from the striatum and hypothalamus: effect of -hydroxybutyrate.来自纹状体和下丘脑的单胺释放：γ-羟基丁酸的作用。
Br J Pharmacol. 1972 Sep;46(1):101-15. doi: 10.1111/j.1476-5381.1972.tb06853.x.
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gamma-Hydroxybutyrate modulates synthesis and extracellular concentration of gamma-aminobutyric acid in discrete rat brain regions in vivo.γ-羟基丁酸在体内调节大鼠离散脑区中γ-氨基丁酸的合成及细胞外浓度。
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Dopamine D(1) receptor facilitation of depolarization-induced release of gamma-amino-butyric acid in rat striatum is mediated by the cAMP/PKA pathway and involves P/Q-type calcium channels.多巴胺D(1)受体促进大鼠纹状体中去极化诱导的γ-氨基丁酸释放是由cAMP/PKA途径介导的，并且涉及P/Q型钙通道。
Synapse. 2007 May;61(5):310-9. doi: 10.1002/syn.20372.

引用本文的文献

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Behavioral effects of gamma-hydroxybutyrate in humans.γ-羟基丁酸对人体的行为影响。
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