Sitren H S, Stevenson N R
J Nutr. 1978 Sep;108(9):1393-401. doi: 10.1093/jn/108.9.1393.
Restricted feeding at two distinct times of the day was associated with different adaptive responses in rats. Animals meal-fed from 1400 to 1800 hours for 6 days demonstrated feeding-cued circadian rhythms in liver weight and in liver transaminase and lactic dehydrogenase enzyme activities. Daily fluctuations in the levels of blood immunoreactive insulin and gastrin were also found to be cued by food intake. By comparison, rats fed from 0700 to 1100 hours for 6 days exhibited altered liver function and blood immunoreactive gastrin patterns. It is suggested that meal-feeding in rats is associated with certain adaptive responses which are dependent upon the timing of the meal. The observed metabolic alterations consequent to meal-feeding are much more apparent in morning-fed than in afternoon-fed animals.
在一天中两个不同时间进行限时喂养与大鼠不同的适应性反应相关。在1400至1800时进行6天的定时进食的动物，其肝脏重量、肝脏转氨酶和乳酸脱氢酶活性呈现出由进食引发的昼夜节律。还发现血液中免疫反应性胰岛素和胃泌素水平的每日波动也由食物摄入引发。相比之下，在0700至1100时进食6天的大鼠肝功能和血液免疫反应性胃泌素模式发生了改变。研究表明，大鼠的定时进食与某些适应性反应相关，这些反应取决于进食时间。定时进食后观察到的代谢改变在上午进食的动物中比在下午进食的动物中更为明显。
