Kaul L, Berdanier C D
J Nutr. 1975 Sep;105(9):1132-40. doi: 10.1093/jn/105.9.1132.
Normal and adrenalectomized rats were either ad libitum fed or meal-fed a 66.5% glucose diet for 1 to 3 weeks. Ad libitum-fed rats exhibited synchronized daily rhythms in the levels of immunoreactive insulin, glucose, hepatic glucose-6-phosphate dehydrogenase, and malic enzyme activities. These rhythms were shifted late-morning 2-hour feeding period. The rhythms of adrenalectomized ad libitum-fed rats were different from those for nonadrenalectomized rats. These results indicate that differences between ad libitum- and meal-fed animals may be attributable to the timing of food intake with respect to the timing of observation rather than to meal-feeding alone. It is further concluded that the adrenals play a role in the maintenance of these rhythms.
正常大鼠和肾上腺切除大鼠随意进食或按餐喂食66.5%葡萄糖饮食1至3周。随意进食的大鼠在免疫反应性胰岛素、葡萄糖、肝葡萄糖-6-磷酸脱氢酶和苹果酸酶活性水平上表现出同步的每日节律。这些节律在上午晚些时候的2小时喂食期发生了变化。肾上腺切除后随意进食的大鼠的节律与未切除肾上腺的大鼠不同。这些结果表明，随意进食和按餐喂食动物之间的差异可能归因于进食时间相对于观察时间的安排，而不仅仅是按餐喂食。进一步得出结论，肾上腺在维持这些节律中起作用。
