Senez P, Gillet J Y
J Gynecol Obstet Biol Reprod (Paris). 1978 May-Jun;7(5):987-90.
The study of 53 pregnancies which were the result of induction of ovulation using a standard treatment with 100 mg of clomiphene citrate and 3 injections of 1,500 I.U. of H.C.G. showed no increase in the risk of fetal malformation. Before treatment this same group of women has a high risk of spontaneous abortion (43p. 100). After treatment in 53 conceptions 7 ended with an abortion which, is 13p. 100. The risks which follow this treatment are above all dominated by the definite increase in twin pregnancies and in prematurity which follows from this factor.
对53例采用100毫克枸橼酸氯米芬标准治疗并注射3次1500国际单位人绒毛膜促性腺激素诱导排卵而怀孕的研究表明,胎儿畸形风险并未增加。治疗前,同一组女性自然流产风险较高(每100例中有43例)。治疗后,53次怀孕中有7例以流产告终,即每100例中有13例。这种治疗带来的风险首先是双胎妊娠的明显增加以及由此导致的早产。