α-二氟甲基鸟氨酸对N-丁基-N-(4-羟丁基)亚硝胺诱导的大鼠膀胱肿瘤的抑制作用
Inhibition of N-butyl-N-(4-hydroxybutyl) nitrosamine-induced urinary bladder tumor in rats by alpha-difluoromethylornithine.
作者信息
Kawahara M, Matsuhashi T, Yagishita T, Tajima M, Matsushima M
出版信息
Hinyokika Kiyo. 1987 Jan;33(1):27-30.
The therapeutic effects of alpha-difluoromethylornithine (DFMO) on rats with bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) were examined. Eight-week-old male Wistar rats were given 0.05% BBN in their drinking water for a period of 4 weeks. Therapy (0.1% DFMO in their drinking water) was started at week 4 and all rats were killed at week 60. DFMO was seen to significantly reduce the incidence, the mean number and the total size of tumors. No side-effects of DFMO were noted, except alopecia, which started at month 7 of the therapy.
研究了α-二氟甲基鸟氨酸（DFMO）对N-丁基-N-（4-羟基丁基）亚硝胺（BBN）诱导的大鼠膀胱肿瘤的治疗效果。给8周龄雄性Wistar大鼠饮用含0.05%BBN的水，持续4周。在第4周开始治疗（饮用含0.1%DFMO的水），所有大鼠在第60周处死。结果发现DFMO能显著降低肿瘤的发生率、平均数量和总体积。除了在治疗第7个月开始出现的脱发外，未观察到DFMO的其他副作用。
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