Marcos R, Xamena N, Creus A
Rev Esp Oncol. 1982;29(3):557-61.
The authors make a brief review of the value of using the fly Drosophila melanogaster to detect possible mutagenic and carcinogenic activities of chemicals. The study of the induction of chromosome X-linked recessive lethal mutations, translocations and chromosomal deletions, and non-disjunction phenomena in Drosophila is very useful to detect direct carcinogenic agents a well as precarcinogenic compounds that are ativated within the fly organism. The assays with Drosophila do not substitute, but follow and complement at a different biological level the assays made in batteries of tests employing bacteria.
作者简要回顾了利用黑腹果蝇检测化学物质可能的诱变和致癌活性的价值。研究果蝇中X染色体连锁隐性致死突变、易位、染色体缺失及不分离现象的诱导，对于检测直接致癌物以及在果蝇体内被激活的前致癌物化合物非常有用。果蝇检测法并不能替代，而是在不同生物水平上跟踪并补充使用细菌进行的一系列测试中的检测方法。
