Wilmshurst P T, Thompson D S, Jenkins B S, Coltart D J, Webb-Peploe M M
Br Heart J. 1983 Jan;49(1):77-82. doi: 10.1136/hrt.49.1.77.
The effects of intravenous amrinone on resting haemodynamic function were investigated in 15 patients with impaired left ventricular function. All patients received 1 X 5 mg/kg and 10 received a further 2 mg/kg. We observed dose related increases in heart rate and cardiac index, and reductions in mean arterial pressure, left ventricular end-diastolic pressure, and systemic vascular resistance. A small reduction in left ventricular end-diastolic volume and a 36% increase in ejection fraction occurred. No significant change in max dp/dt, min dp/dt, (Max dp/dt/P), max (dp/dt/P), KVmax or the ratio of left ventricular end-systolic pressure to left ventricular end-systolic volume was detected. It is concluded that the beneficial effects of intravenous amrinone on the resting haemodynamics in our patients were attributable to vasodilatation, with the drug having no demonstrable positive inotropic effect.
对15例左心室功能受损患者研究了静脉注射氨力农对静息血流动力学功能的影响。所有患者均接受1×5mg/kg的剂量，10例患者还接受了2mg/kg的额外剂量。我们观察到心率和心脏指数呈剂量相关增加，平均动脉压、左心室舒张末期压力和全身血管阻力降低。左心室舒张末期容积略有减少，射血分数增加36%。未检测到最大dp/dt、最小dp/dt、（最大dp/dt/P）、最大（dp/dt/P）、KVmax或左心室收缩末期压力与左心室收缩末期容积之比有显著变化。得出的结论是，静脉注射氨力农对我们患者静息血流动力学的有益作用归因于血管舒张，该药物没有明显的正性肌力作用。
