Austad J, Møork N J
Br J Dermatol. 1983 Jan;108(1):63-7. doi: 10.1111/j.1365-2133.1983.tb04579.x.
Guinea-pigs, previously sensitized to dinitrochlorobenzene (DNCB), were exposed to varying doses of UV-C radiation (254 nm) on one of the flanks for a period of 15 days. They were then patch-tested with DNCB immediately after UV treatment. The responses to DNCB were diminished both in the irradiated and non-irradiated skin compared with control animals which had not received UV-C radiation. This effect was dose dependent and could only be demonstrated for a limited period of time. Guinea-pig exposed to UV-C radiation did not show a decreased response to sodium lauryl sulphate, which is a potent irritant. The influence of UV-C on delayed hypersensitivity therefore seems to be an immunological effect.
预先对二硝基氯苯（DNCB）致敏的豚鼠，在一侧胁腹接受不同剂量的UV - C辐射（254纳米），持续15天。然后在紫外线处理后立即用DNCB进行斑贴试验。与未接受UV - C辐射的对照动物相比，照射皮肤和未照射皮肤对DNCB的反应均减弱。这种效应呈剂量依赖性，且仅在有限的时间段内可被证实。暴露于UV - C辐射的豚鼠对强刺激剂十二烷基硫酸钠的反应并未降低。因此，UV - C对迟发型超敏反应的影响似乎是一种免疫效应。
