Egwuatu V E
Br J Obstet Gynaecol. 1983 Jan;90(1):21-5. doi: 10.1111/j.1471-0528.1983.tb06740.x.
Plasma concentrations of urea, uric acid and creatinine were measured in 55 normal primigravid Nigerians during pregnancy and 6 weeks after delivery. Plasma urate concentrations were lowest in early pregnancy and increased with advancing gestation, achieving the highest values in the postnatal period. These findings are similar to those reported for European women. Plasma urea rose during the second trimester, fell in the third to almost first trimester levels and rose again in the postnatal period. Plasma creatinine generally followed the same pattern as urea. It is suggested that these changes are a reflection of fluid distribution rather than a change in urea and creatinine production. An improved nutritional status may explain the urea values which are higher than previously reported in African women.
在55名正常初孕的尼日利亚孕妇孕期及产后6周测量了血浆尿素、尿酸和肌酐浓度。血浆尿酸盐浓度在妊娠早期最低，并随孕周增加而升高，在产后达到最高值。这些发现与欧洲女性的报道相似。血浆尿素在孕中期升高，在孕晚期降至几乎孕早期水平，并在产后再次升高。血浆肌酐通常与尿素呈现相同模式。提示这些变化反映的是液体分布情况，而非尿素和肌酐生成的改变。营养状况改善或许可以解释非洲女性高于此前报道的尿素值。
