Letvin N L, Todd R F, Palley L S, Schlossman S F, Griffin J D
Blood. 1983 Feb;61(2):408-10.
Monoclonal antibodies reactive with myeloid cell surface antigens were used to study evolutionary changes in granulocyte surface antigens from primate species. Certain of these granulocyte membrane antigens are conserved in phylogenetically distant species, indicating the potential functional importance of these structures. The degree of conservation of these antigens reflects the phylogenetic relationship between primate species. Furthermore, species of the same genus show similar patterns of binding to this panel of anti-human myeloid antibodies. This finding of conserved granulocyte surface antigens suggests that non-human primates may provide a model system for exploring uses of monoclonal antibodies in the treatment of human myeloid disorders.
与髓样细胞表面抗原反应的单克隆抗体被用于研究灵长类动物物种粒细胞表面抗原的进化变化。这些粒细胞膜抗原中的某些在系统发育上相距甚远的物种中是保守的，这表明这些结构具有潜在的功能重要性。这些抗原的保守程度反映了灵长类动物物种之间的系统发育关系。此外，同一属的物种对这组抗人髓样抗体显示出相似的结合模式。粒细胞表面抗原保守这一发现表明，非人灵长类动物可能为探索单克隆抗体在治疗人类髓样疾病中的应用提供一个模型系统。
