Fischer C P, Diokno A, Lapides J
J Urol. 1978 Sep;120(3):328-9. doi: 10.1016/s0022-5347(17)57158-x.
A preliminary study to assess objectively the effects of dicyclomine upon uncontrolled detrusor contractions and bladder capacity was undertaken in 14 patients with a cystometric diagnosis of uninhibited neurogenic bladder. Response was measured by cystometry performed 1, 2 and 4 hours after a 20 mg. oral dose. Of the 14 patients 11 had significant blockade of uninhibited contractions and a concomitant increase in bladder capacity. Similar but less dramatic changes were noted in the remaining 3 patients. Dicyclomine seems to have effective anticholinergic properties. No remarkable side effects were observed.
对14例经膀胱测压诊断为无抑制性神经源性膀胱的患者进行了一项初步研究，以客观评估双环维林对不受控制的逼尿肌收缩和膀胱容量的影响。在口服20毫克剂量后1小时、2小时和4小时进行膀胱测压来测量反应。14例患者中有11例无抑制性收缩得到显著阻断，膀胱容量随之增加。其余3例患者也观察到类似但不太明显的变化。双环维林似乎具有有效的抗胆碱能特性。未观察到明显的副作用。
