Awad S A, Bryniak S, Downie J W, Bruce A W
J Urol. 1977 Feb;117(2):161-3. doi: 10.1016/s0022-5347(17)58381-0.
Symptomatic treatment of the uninhibited bladder has presented a challenge because of the lack of an effective, well tolerated smooth muscle relaxant for the bladder that can be used during an extended interval. In a preliminary study oral dicyclomine produced resolution or significant improvement of symptoms in 24 of 27 patients and an increase in bladder capacity by an average of 137 plus or minus 26 ml. (91 plus or minus 22 per cent) after 8 weeks of therapy. Additional controlled trials definitely are warranted.
由于缺乏一种有效且耐受性良好的膀胱平滑肌松弛剂，无法在较长时间内使用，因此对无抑制膀胱进行对症治疗一直是一项挑战。在一项初步研究中，口服双环胺使27例患者中的24例症状得到缓解或显著改善，治疗8周后膀胱容量平均增加137±26毫升（91±22%）。肯定需要进行更多的对照试验。
