Wilson D A, Sullivan R M
Department of Psychology, University of Oklahoma, Norman 73019.
Behav Neurosci. 1991 Dec;105(6):843-9. doi: 10.1037//0735-7044.105.6.843.
One of the circuits modified by early olfactory learning is in the olfactory bulb. Specifically, response patterns of mitral-tufted cells are modified by associative conditioning during the early postnatal period. In addition, previous work has demonstrated that mitral-tufted cell single units respond to both olfactory conditioned stimuli and rewarding stimulation of the medial forebrain bundle-lateral hypothalamus (MFB-LH). The present study suggests that norepinephrine beta-receptor activation is required for early olfactory learning using MFB-LH stimulation as reward. Propranolol injected before odor-MFB-LH pairings blocks the acquisition of conditioned behavioral responses and their neural correlates to the conditioned odor. Furthermore, propranolol blocks a specific class of the mitral-tufted cell responses to MFB-LH reward stimulation. The relationship of this response to reward and early learning is discussed.
早期嗅觉学习所改变的其中一个神经回路位于嗅球。具体而言，在出生后的早期阶段，通过联合条件作用可改变僧帽-簇状细胞的反应模式。此外，先前的研究表明，僧帽-簇状细胞单个单元对嗅觉条件刺激以及内侧前脑束-外侧下丘脑（MFB-LH）的奖赏性刺激均有反应。本研究表明，以MFB-LH刺激作为奖赏进行早期嗅觉学习需要去甲肾上腺素β受体激活。在气味与MFB-LH配对之前注射普萘洛尔会阻断条件性行为反应的习得及其与条件气味的神经关联。此外，普萘洛尔会阻断僧帽-簇状细胞对MFB-LH奖赏刺激的一类特定反应。本文讨论了这种反应与奖赏及早期学习的关系。
